Between-host Evolution of Mutation-rate and Within-host Evolution of Virulence
نویسنده
چکیده
It has been recently realized that parasite virulence (the harm caused by parasites to their hosts) can be an adap-tive trait. Selection for a particular level of virulence can happen either at at the level of between-host tradeoos or as a result of shortsighted within-host competition. This paper describes some simulations which study the eeect that mod-iier genes for changes in mutation rate have on suppressing this shortsighted development of virulence, and investigates the interaction between this and a simpliied model of immune clearance.
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تاریخ انتشار 2007